Product Details

1.Introduction

S-Adenosyl-L-Methionine Powder , also know as SAMe,  is a physiologically active molecule that exists in human tissues. It is synthesized by SAMe synthase catalyzing methionine and ATP. It acts as a methyl donor and a precursor of physiological sulfhydryl compounds to participate in chemical reactions in the body.

2.Main Function

1).Improve depression

*In the cerebrospinal fluid of depressed patients, the lower the concentration of 5-HIAA (a metabolite of 5-hydroxytryptophan), the more severe the depression. Supplementation of exogenous SAMe may promote the synthesis of 5-HIAA.

2).Antioxidant, reduce liver cell damage

*Significantly reduce the level of reactive oxygen species (ROS) in ethanol-treated liver cells.

*Promote the production of endogenous glutathione, improve detoxification and antioxidant function.

3).Detoxification, resist the damage of harmful substances to liver cells

*Promote the production of endogenous glutathione, improve detoxification and antioxidant function. Repair liver cells, improve membrane fluidity, increase the enzyme activity of Na+-K+-ATP, repair cytoskeleton, and improve liver cell function

*Protection of cell membrane: protect the lipid environment of cell membrane, maintain the enzymatic activity of Na+-K+-ATP of normal liver cell membrane and improve bile process and secretion.

*Protect the cytoskeleton: prevent the destruction of bile duct function caused by encircling toxin A (CyA); reduce the formation of micronucleus cells caused by cytoskeleton destruction drugs; protect the integrity of microtubules.

4).Promote liver cell regeneration

*Significantly increase the mitotic activity of liver cells in the early stage

5).Anti-liver fibrosis, delay the progression of liver disease

*S-Adenosyl-L-Methionine Powder can inhibit the activation of hepatic stellate cells.

*It can inhibit the expression of TNF and promote the expression of IL-10, thereby inhibiting inflammation and combating liver fibrosis.

6).Increase insulin sensitivity and improve lipid metabolism

*Can increase mtDNA density and improve insulin sensitivity

3.Application

S-Adenosyl-L-Methionine Powder can be widely used in health products and pharmaceuticla products.

4.Quality Standard

According to USP37

5.Method of Analysis

6.HPLC TEST

7.Stability and Safety

Stability:

Stable under proper conditions(room temperature). Stability Data Sheet is available upon your request.
Safety:

According to U.S. NCCIH, in one study of alcohol-related liver disease, participants took SAMe for 2 years; in that study, no serious side effects were reported.

8.Flow Chart

9.Customer Comments

We have shops on Alibaba, Chemicalbook and LookChem, through high quality products and unreserved services, we have gained a lot of favourable comments.

10.Our Certificates

Over the years, we have been committed to the product manufacture optimization and quality system establishment. We've set up the quality management system and obtained certificates of it.

11.Our Clients

We've established business relationship with Abbott, Unilever, Shiseido, KANS and SIMM, etc.

12.Exhibitions

We often attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.

http://www.konochem.com/